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pYou are allergic to any ingredient in Micronase you have type 1 diabetes or certain severe problems associated with diabetesegdiabetic ketoacidosisdiabetic comayou have moderate to severe burns or very high blood acid levelsacidosisyou are pregnant and are within 2 weeks of the expected delivery date you are taking bosentan./ppIn addition to dermatologic reactionsallergic reactions such as angioedemaarthralgiamyalgia and vasculitis have been reported./ppGlyburideMicronaseDiabetaGlynase Prestabis a drug prescribed for the treatment of type 2 diabetesIt is recommended that glyburide be combined with diet and exercise for controlling blood glucose levelsSide effectsdrug interactionsdosageand safety during pregnancy should be reviewed prior to taking this medication./ppThe effectiveness of any hypoglycemic drugincluding MICRONASEin lowering blood glucose to a desired level decreases in many patients over a period of time which may be due to progression of the severity of diabetes or to diminished responsiveness to the drugThis phenomenon is known as secondary failureto distinguish it from primary failure in which the drug is ineffective in an individual patient when MICRONASE is first givenAdequate adjustment of dose and adherence to diet should be assessed before classifying a patient as a secondary failure./p

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